Transferinski receptor
Transferinski receptor (TfR) je prenosni protein za transferin. On je potreban za unos gvožđa u ćeliju i kontrolisan je intraćelijskom koncentracijom gvožđa. On unosi gvožđe internalizacijom kompleksa transferin-gvožđe putem endocitoze posredovane receptorom.[1]
| Transferinski receptor (p90, CD71) | |
|---|---|
 | |
| Dimer transferinskog receptora 1 (čovjek) | |
| Identifikatori | |
| Simbol | TFRC |
| Alt. simboli | CD71, TFR1 |
| Entrez | 7037 |
| HUGO | 11763 |
| OMIM | 190010 |
| RefSeq | NM_003234 |
| UniProt | P02786 |
| Drugi podaci | |
| Lokus | Hromozom 3 q29 |
| Transferinski receptor 2 | |
|---|---|
| Identifikatori | |
| Simbol | TFR2 |
| Alt. simboli | HFE3, TFRC2 |
| Entrez | 7036 |
| Hugo | 11762 |
| OMIM | 604720 |
| RefSek | NM_003227 |
| UniProt | Q9UP52 |
| Drugi podaci | |
| Lokus | Hrom. 7 q22 |
Regulacija
urediNiske koncentracije gvožđa podstiču povećanje nivoa transferinskog receptora, da bi se povećao unos gvožđa u ćeliju. Transferinski receptor učestvuje u održavanju ćelijske homeostaze gvožđa.
TfR produkcija u ćeliji je regulisana nivoima gvožđa posredstvom IRE-BP proteina (respons na gvožđe/regulatorni element vezivanja proteina), koji se naziva i regulatorni protein gvožđa (engl. Iron Regulatory Protein - IRP). Taj protein se vezuje za strukturu sličnu ukosnici na 3' UTR TfR receptora. Nakon vezivanja dolazi do inhibicije degradacije iRNK za IRE.
Reference
uredi- ↑ Qian ZM, Li H, Sun H, Ho K (December 2002). „Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway”. Pharmacol. Rev. 54 (4): 561–87. DOI:10.1124/pr.54.4.561. PMID 12429868.; Figure 3: The cycle of transferrin and transferrin receptor 1-mediated cellular iron uptake.[mrtav link]
Literatura
uredi- Testa U, Kühn L, Petrini M, Quaranta MT, Pelosi E, Peschle C (July 1991). „Differential regulation of iron regulatory element-binding protein(s) in cell extracts of activated lymphocytes versus monocytes-macrophages”. J. Biol. Chem. 266 (21): 13925–30. PMID 1856222.
- Daniels TR, Delgado T, Rodriguez JA, Helguera G, Penichet ML (November 2006). „The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer”. Clin. Immunol. 121 (2): 144–58. DOI:10.1016/j.clim.2006.06.010. PMID 16904380.; Figure 3: Cellular uptake of iron through the Tf system via receptor-mediated endocytosis. Arhivirano 2015-09-24 na Wayback Machine-u
- Daniels TR, Delgado T, Helguera G, Penichet ML (November 2006). „The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells”. Clin. Immunol. 121 (2): 159–76. DOI:10.1016/j.clim.2006.06.006. PMID 16920030.
Vidi još
urediSpoljašnje veze
uredi- MeSH Transferrin+receptor
- Okam M (29. 01. 2001.). „Transerrin and Iron Transport Physiology”. Information Center for Sickle Cell and Thalassemic Disorders. Brigham and Women's Hospital and Harvard Medical School. Pristupljeno 19. 12. 2010.