Inhibitor receptorii angiotensini II
Inhibitores receptorii angiotensini II vel antagonistae receptori AT1 vel brevius sartani sunt grex medicamentorum cum effectibus praecipue antihypertensivis, qui ad systematem renini-angiotensini-aldosteroni efficacem contra hypertensionem arterialis sunt.[1] Cunctorum inhibitorum receptorii angiotensini II Codex ATC est C09CA.
Effectibus similes sunt inhibitores enzymi angiotensinum convertentes, qui non angiotensini II receptoria obsident sed enzymum angiotensinum II formantem. Verbis aliis: Inhibitores enzymi angiotensinum convertentis prae angiotensinum II, verum hi inhibitores receptorii angiotensini II post angiotensinum II agunt.
Historia recensere
Anno 1898, Robertus Tigerstedt physiologus Finnicus primus enzymum renini inter renes et systematem cardiovasculare connectere descripsit.[2]
Substantia singulares recensere
| Codex ATC | Substantia | DDD (mg) | Vasopressionis inhibitio [gradus / dosis] | Tempus semivitae biologicum (horae) |
|---|---|---|---|---|
| C09CA01 | Losartanum | 50 | 30% / 100mg | 7 (6-9) |
| C09CA02 | Eprosartanum | 600[3] | ||
| C09CA03 | Valsartanum | 80 | 30% / 80mg | 6 |
| C09CA04 | Irbesartanum | 150[4] | 40%/ 150mg | 13 (11-15) |
| C09CA05 | Tasosartanum | |||
| C09CA06 | Candesartanum | 8 | 9 | |
| C09CA07 | Telmisartanum | 40 | 40% / 80mg | 24 |
| C09CA08 | Olmesartanum | 20 | 61% / 20mg | 13 |
| C09CA09 | Azilsartanum | 40 | 60% / 32mg | 11 |
| C09CA10 | Fimasartanum | 9 (7-11) |
Systema classificationis Anatomicum Therapeuticum Chemicumque has substantias includit:
- Losartanum
- Eprosartanum
- Valsartanum
- Irbesartanum
- Tasosartanum
- Candesartanum
- Telmisartanum
- Olmesartanum
- Azilsartanum
- Fimasartanum
Nonnulli inhibtores receptorii angiotensini, qui adhuc nondum in Systemate classificationis Anatomici Therapeutici Chemicique invenitur sunt:
Notae recensere
- ↑ Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (Aprilis 2007). "Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology". Clin Sci 112: 417–28.
- ↑ Cleland S. J., Reid J. L. (1996). "The renin-angiotensin system and the heart: a historical Review". Heart 76 (suppl 3): 7–12.
- ↑ Ordo mundi sanitarius: 0.6g
- ↑ Ordo mundi sanitarius: 0.15g
- ↑ Pubchem de EXP-3174
- ↑ http://www.drugbank.ca/drugs/DB01347