Simeticone

Simeticone
Clinical data
Trade names	Infacol, Wind-eze, WindSetlers, many others
Other names	simethicone (USAN US)
AHFS/Drugs.com	Monograph
Pregnancy; category	C;
Routes of; administration	Oral
ATC code	A03AX13 (WHO) ;
Legal status
Legal status	US: OTC;
Pharmacokinetic data
Bioavailability	None
Protein binding	0%
Metabolism	Not metabolized
Elimination half-life	N/A
Excretion	Feces
Identifiers
	IUPAC name Poly(dimethylsiloxane), silicon dioxide;
CAS Number	8050-81-5 ;
PubChem CID	6433516;
DrugBank	DB09512 ;
ChemSpider	None;
ChEMBL	ChEMBL1200838 ;
CompTox Dashboard (EPA)	DTXSID00904918 ;
ECHA InfoCard	100.107.016
Chemical and physical data
Formula	(C2H6OSi)n · (SiO2)m
Molar mass	Variable
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Simeticone (INN), also known as simethicone (USAN), is an anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas.

Medical uses

Simeticone is used to relieve the symptoms of excessive gas in the gastrointestinal tract, namely bloating, burping, and flatulence.^[2]^[3] While there is a lack of conclusive evidence that simeticone is effective for this use,⁣^[4]^[5]^{[failed verification]} studies have shown that it can relieve symptoms of functional dyspepsia^[6] and functional bloating.^[7]

It has not been fully established that simeticone is useful to treat colic in babies,^[8] and it is not recommended for this purpose.^[5] A study in the United Kingdom reported that according to parental perception simeticone helped infant colic in some cases.^[9]

Simeticone can also be used for suspected postoperative abdominal discomfort in infants.^[10]

Side effects

Simeticone does not have any serious side effects.^[11] Two uncommon side effects (occurring in 1 in 100 to 1 in 1,000 patients) are constipation and nausea.^[12]

Pharmacology

Simeticone is a non-systemic surfactant which decreases the surface tension of gas bubbles in the GI tract.^[11] This allows gas bubbles to leave the GI tract as flatulence or belching.^[11] Simeticone does not reduce or prevent the formation of gas.^[13] Its effectiveness has been shown in several in vitro studies.^[14]^[15]

Chemistry

Simeticone is a mixture of dimethicone and silicon dioxide.^[16]

Names

The INN name is "simeticone", which was added to the INN recommended list in 1999.^[17]

Simeticone is marketed under many brand names and in many combination drugs; it is also marketed as a veterinary drug.^[18]

Brands

Brand names include A.F., Acid Off, Aero Red, Aero-OM, Aero-Sim, Aerocol, Aerox, Aesim, Aflat, Air-X, Anaflat, Antiflat, Baby Rest, Bicarsim, Bicarsim Forte, Blow-X, Bobotic, Bobotik, Carbogasol, Colic E, Colin, Cuplaton, Degas, Dentinox, Dermatix, Digesta, Dimetikon Meda, Disflatyl, Disolgas, Elugan N, Elzym, Endo-Paractol, Enterosilicona, Espaven Antigas, Espumisan, Espumisan L, Flacol, Flapex, Flatidyl, Flatoril, Flatulex, Flucolic, Gas X, Gas-X, Gaselab, Gaseoflat, Gaseoflatex, Gaseophar, Gaseoplus, Gaseovet, Gaservol, Gasimetin, Gasnil, Gasofilm, Gastrex, Gastrosen, Gazim X, Gazix, Geludrox-HS, Genasyme, Ilio-Funkton, Imogas, Imogaze, Imonogas, Infacalm, Infacol, Infacolic, Lefax, Lefaxin, Lefoam, Logastin, Luftal, Maxi Flat, Meteosim, Metiorisan, Metsil, Mylanta, Mylicon, Mylicongas, Mylom, Mymus, Nanog, Neodrop, Neogasol, Neolanta, Orocure, Ovol, Pedicon, Phazin, Phazyme, Restime, Rugby Gas Relief, Sab Simplex, Salinal, Semecon, Semeth, Sicongast, Siflat, Silbione, Siligas, Silipin, Sim, Simcone, Simecon, Simecrin, Simedill, Simegut, Simet, Simethicon, Simethicone, Simetic, Simeticon, Simeticona, Simeticone, Siméticone, Simeticonum, Simetigast, Simflat, Simicol, Simicon, Wilcon, Wind-eze and WindSetlers.^[18]

It is also marketed as a combination drug:^[18]

with algeldrate as Kestomatine
with aluminium or magnesium salts and in some cases both, as Alamag Plus, Almacone, Alposim, Aluphagel, Alutop, Amico-L Andursil, Axcel Eviline, Boots Wind Relief, Di-Gel, Diovol Plus, Diovol Plus AF, Gas Ban DS, Hydrosil, Iosopan Plus, Kremil, Kremil-S, Maalox Plus, Mi-Acid, Mygel, Mylagen, Polysilane Delalande, Rumibex and Trial AG
with alverine as Avarin, Meteospasmyl, Nady-Spasmyl
with barium sulfate as Bario Dif
with bismuth as Gastop
with calcium carbonate as Flamints, Gaseoflatex Plus, Malugel, Titralac Plus
with activated charcoal as Carbosylane, Clingest, Finigax. Flatuna
with cinitapride as Rogastril Plus
with clebopride as Flatoril
with dicycloverine as Cloact, Colicspam, Colimix, Colispas, Coliza-D, Cyclopam, Fri-Spas, Meftal Spas, Respas, Simcomine, Spasact, Spasmindon DPS
with domperidone as Bigetric, Dom Simecon, Doprokin-S, Glomoti, Moperidona AF, Mutecium, Praxis
with hydrotalcite as Altacide and Talsil Forte
with homatropine as Aero-Sim Compuesto, Asestor, Factor AG, Sedotropina Flat
with lactulose as Dinolak
with levonorgestrel as Jaydess
with loperamide as Eldoper Plus, Imodium Duo, Imolopesim, Loperamide HCl/Dimeticon, Loperuma, Lositala, Losiwuto, Regulane AF, Stoperan Plus, Toban F Plus
with magaldrate as Aci Basic, Aci-Tip, Acicone-S, Acid-Farvet, Acifin, Amalset, Antiax, Asidrat, Assis, Avicid, Banacid-s, Buenox, Cremalon, Curecid, Digax, Digeril, Endcid, Gaseovet MS, Gastrine, Gastrogel, Gastroral, Gastrorapid, Magacid, Magal-D, Magalat, Magaldrato+Simeticona, Magaldrax, Maganta Plus, Magsilon, Marlox Plus, Megacil Plus, Megalrat Plus, Minicidez, Miopan Plus, Novelta, Oxecone-MS, Riopan Plus, Rolac Plus, Sedo Mag, Simagal, Simelgat Plus, Taimacon, Zymcon
with metoclopramide as Anaflat Compuesto, Di-Aero OM, Digespar, Factorine, Pangastren
with mosapride as M-Pride-MPS, Moxar, Moza MPS
with pancreatin as Anaflat Enzimático, Digenil, Digesflat, Enzym Lefax, Enzymet, Enzymin, fermento duodenal, Finigax Indigestion, Flaton, Flazymec, Gasflat, Gaszym, Gesdyp, Hazmolin, Komflat, MeteoZym, Pankreoflat, Tripanzym
with papaverine as Espasmo Siligas
with pinaverium as Alevian Duo, Pladuet, Planex
with pipenzolate bromide as Cadinol, Gasorbol Gotas
with phloroglucinol as Meteoxane
with trimebutine as Eumotil-S, Eumotrix Plus, Libertrim SDP, Libertrim SII, Muvett S
with urea as Hidribet.

It is also marketed as a veterinary drug under the brands Birp and Methysilox.

References

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