Sulfotransferase 1A3/1A4 is an enzyme that in humans is encoded by the SULT1A3 gene.[3][4][5]

SULT1A3
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesSULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST, ST1A3, sulfotransferase family 1A member 3, ST1A4
External IDsOMIM: 600641; HomoloGene: 133085; GeneCards: SULT1A3; OMA:SULT1A3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001017387
NM_003166
NM_177552

n/a

RefSeq (protein)

NP_808220
NP_001017390
NP_001017390.1
NP_808220.1
NP_001017390

n/a

Location (UCSC)Chr 16: 30.2 – 30.2 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1). Three alternatively spliced variants that encode the same protein have been described.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000261052Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Wood TC, Aksoy IA, Aksoy S, Weinshilboum RM (Mar 1994). "Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization". Biochem Biophys Res Commun. 198 (3): 1119–27. doi:10.1006/bbrc.1994.1159. PMID 8117269.
  4. ^ Aksoy IA, Callen DF, Apostolou S, Her C, Weinshilboum RM (Feb 1995). "Thermolabile phenol sulfotransferase gene (STM): localization to human chromosome 16p11.2". Genomics. 23 (1): 275–7. doi:10.1006/geno.1994.1494. PMID 7829089.
  5. ^ a b "Entrez Gene: SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3".

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: P0DMM9 (Sulfotransferase 1A3) at the PDBe-KB.