28S ribosomal protein S6, mitochondrial is a protein that in humans is encoded by the MRPS6 gene.[5]

MRPS6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS6, C21orf101, MRP-S6, RPMS6, S6mt, mitochondrial ribosomal protein S6
External IDsOMIM: 611973; MGI: 2153111; HomoloGene: 41871; GeneCards: MRPS6; OMA:MRPS6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032476

NM_080456

RefSeq (protein)

NP_115865

NP_536704

Location (UCSC)Chr 21: 34.07 – 34.14 MbChr 16: 91.86 – 91.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000243927Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039680Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MRPS6 mitochondrial ribosomal protein S6".

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: P82932 (28S ribosomal protein S6, mitochondrial) at the PDBe-KB.