List of largest selling pharmaceutical products

Best selling pharmaceuticals of U.S. market

The top 5 best selling pharmaceuticals 2015–2019. Sales in billion USD.^[1]

Rank	Drug	Main indication	Trade name	2015	2016	2017	2018	2019
1	adalimumab	rheumatoid arthritis	Humira	10.1	13.5	16.3	18.4	21.4
2	apixaban	anticoagulant	Eliquis	1.6	3.0	4.6	7.1	9.9
3	etanercept	rheumatoid arthritis	Enbrel	7.2	7.6	7.9	8.0	8.1
4	ustekinumab	psoriasis	Stelara	2.0	2.6	3.7	5.0	6.6
5	pembrolizumab	oncology	Keytruda	0.4	0.7	2.2	4.3	6.5

Best selling pharmaceuticals of 2017/18

The top 16 best selling pharmaceuticals of 2017/18.^[2]


Rank	Drug	Main indication	Trade name	2018 sales (million USD)	2017 sales (million USD)
1	adalimumab	rheumatoid arthritis	Humira	19 936	18427
3	apixaban	anticoagulant	Eliquis	9872	7395
4	lenalidomide	multiple myeloma	Revlimid	9685	8187
5	nivolumab	oncology	Opdivo	7570	5763
6	pembrolizumab	oncology	Keytruda	7171	3809
7	etanercept	rheumatoid arthritis	Enbrel	7126	7885
8	trastuzumab	breast cancer	Herceptin	6981	7013
9	bevacizumab	colon cancer	Avastin	6847	6686
10	rituximab	non-Hodgkin's lymphoma	Rituxan, MabThera	6750	7298
11	rivaroxaban	anticoagulant	Xarelto	6589	6234
12	aflibercept		Eylea	6551	5830
13	infliximab		Remicade	5908	7152
14	Pneumococcal conjugate vaccine		Prevnar 13 Prevenar 13	5802	5601
15	ustekinumab		Stelara	5156	4011
16	pregabalin	epilepsy	Lyrica	4970	5065

Largest selling pharmaceutical products of 2015

Drugs with sales above $5 billion in 2015 included:^[3]^[4]

Rank	Drug	Trade name	Type	Main indications	Company	Sales (USD millions/year)	∆ vs 2014
1	Adalimumab	Humira	Biologic	Rheumatoid arthritis	AbbVie Inc.	14,012	1,469
2	Ledipasvir/sofosbuvir	Harvoni	Small molecule	Hepatitis C	Gilead Sciences	13,864	11,737
3	Etanercept	Enbrel	Biologic	Rheumatoid arthritis	Amgen Pfizer	8,697	4,009
4	Infliximab	Remicade	Biologic	Crohn's Disease Rheumatoid Arthritis	Johnson & Johnson	8,355	1,487
5	Rituximab	Mabthera Rituxan	Biologic	Lymphoma Leukemia Autoimmune disorders	Roche Genentech	7,115	1,456
6	Insulin glargine	Lantus	Biologic	Diabetes mellitus	Sanofi	7,029	51
7	Bevacizumab	Avastin	Biologic	Metastatic cancers	Roche Genentech	6,751	270
8	Trastuzumab	Herceptin	Biologic	Breast cancer	Roche Genentech	6,603	265
9	Lenalidomide	Revlimid	Small molecule	Multiple myeloma Myelodysplastic syndromes	Celgene	5,801	821
10	Sofosbuvir	Sovaldi	Small molecule	Hepatitis C	Gilead Sciences	5,276	(5,007)
11	Fluticasone propionate/salmeterol	Seretide Advair	Small molecule	Asthma Chronic obstructive pulmonary disease	GlaxoSmithKline	5,227	(778)
12	Rosuvastatin	Crestor	Small molecule	Cardiovascular diseases	AstraZeneca	5,017	(495)

Best selling pharmaceuticals of 2013

For the fourth quarter of 2013, the largest selling drugs were:^[5]

Rank	Brand Name(s)	Generic Name	Sales Q1 2014 Sales ($000)	Change from Q4 2013	Company(ies)	Disease/Medical Use	First Approval Date	Patent Expiration Date^[6]^[7]
1	Abilify	Aripiprazole	1,602,329	2.23%	Generic	Psychosis, mania, and depression	Nov-2002	2014-Oct
2	Humira	Adalimumab	1,561,861	3.86%	AbbVie	Crohn's disease; Rheumatoid arthritis	Dec-2002	2016-Dec
3	Nexium	Esomeprazole	1,536,435	0.74%	Generic	Gastrointestinal disorders	Mar-2000	2014-May
4	Crestor	Rosuvastatin	1,333,502	4.53%	AstraZeneca, Shionogi	Cholesterol	Nov-2002	2016-Jul
5	Enbrel	Etanercept	1,189,844	1.46%	Amgen	Rheumatoid arthritis	Nov-1998	2012-Oct
6	Advair Diskus, Seretide	Fluticasone/salmeterol	1,147,330	2.65%	GlaxoSmithKline	Asthma	Aug-2000	2012-Mar
8	Remicade	Infliximab	994,020	-2.71%	Centocor Ortho Biotech, Inc., Mitsubishi Tanabe Pharma	Crohn's disease; rheumatoid arthritis	Aug-1998	n/a
9	Lantus Solostar	Insulin glargine	939,691	9.39%	Sanofi-Aventis	Diabetes mellitus type 1 and 2	Apr-2000	2011-Dec
10	Neulasta	Pegfilgrastim	854,508	-4.90%	Amgen	Neutropenia	Jan-2002	Mon-20XX
11	Copaxone	Glatiramer	851,351	-4.69%	Generic	Multiple sclerosis	Dec-1996	Nov-2014
12	Rituxan, MabThera	Rituximab	746,766	-0.16%	Biogen Idec, Chugai Pharmaceutical, Genentech/Roche	Non-Hodgkin’s lymphoma; rheumatoid arthritis	Nov-1997	Mon-20XX
13	Spiriva	Tiotropium bromide	726,057	3.39%	Boehringer Ingelheim	Chronic obstructive pulmonary disease	Apr-2002	2018-Jul
14	Januvia	Sitagliptin	700,941	3.63%	Merck & Co., Inc.	Diabetes mellitus type 2	Dec-1996	2017-Nov
15	Lantus	Insulin glargine	685,461	5.84%	Sanofi-Aventis	Diabetes mellitus type 1 and 2	Apr-2000	Dec-2011
16	Atripla	Emtricitabine/tenofovir/efavirenz	679,418	0.36%	Gilead Sciences, Inc.	HIV infection	Dec-1996	Mar-2015
17	Cymbalta	Duloxetine	664,186	-23.06%	Generic	Depression; anxiety disorders	Aug-2004	Dec-2013
18	Avastin	Bevacizumab	650,208	-1.25%	Genentech/Roche	Cancer	Feb-2004	Mon-20XX
19	Lyrica	Pregabalin	624,774	2.82%	Pfizer	Neuropathic pain	Jul-2004	Jul-2019
20	OxyContin	Oxycodone	585,482	-2.91%	Generic	Pain	Dec-1996	Mon-20XX
21	Celebrex	Celecoxib	580,332	5.23%	Generic	Osteoarthritis; rheumatoid arthritis	Dec-1998	May-2014
22	Epogen	Epoetin alfa	503,493	-2.08%	Amgen	Anemia	Jun-1989	Mon-20XX
23	Truvada	Tenofovir/emtricitabine	542,846	0.03%	Gilead Sciences	HIV infection	Aug-2004	Mon-20XX
24	Diovan	Valsartan	533,924	-2.80%	Generic	Hypertension	Dec-1996	Sep-2012
25	Levemir	Insulin detemir	424,186	9.34%	Novo Nordisk	Diabetes mellitus type 1 and 2	Dec-1990	Mon-20XX
26	Gleevec, Glivec	Imatinib	498,149	7.22%	Novartis	Leukemia	May-2001	Jan-2015
27	Herceptin	Trastuzumab	473,632	1.53%	Chugai Pharmaceutical, Genentech/Roche	Breast cancer	Sep-1998	Mon-20XX
28	Vyvanse	Lisdexamfetamine	447,188	9.39%	Shire	Attention deficit hyperactivity disorder	Apr-2008	Mon-20XX
29	Lucentis	Ranibizumab	460,621	-0.84%	Genentech	Macular degeneration	Dec-1990	Mon-20XX
30	Zetia	Ezetimibe	444,731	4.04%	Merck & Co., Schering-Plough	Cholesterol	Oct-2002	2017-Oct
31	Combivent	Ipratropium bromide/salbutamol	391,404	20.28%	Boehringer Ingelheim	Chronic obstructive pulmonary disease	Oct-1996	Mon-20XX
32	Symbicort	Budesonide/formoterol	407,646	9.63%	AstraZeneca	Asthma	Aug-2000	Mon-20XX
33	Namenda	Memantine	434,766	-6.00%	Generic	Alzheimer's disease	Oct-2003	Apr-2014 ^[9]
34	NovoLog FlexPen	Insulin aspart	364,870	7.84%	Novo Nordisk	Diabetes mellitus type 1 and 2	Oct-1996	Mon-20XX
35	Xarelto	Rivaroxaban	321,462	18.72%	Bayer	Oral anticoagulant	Dec-1996	Sep-2012
36	NovoLog	Insulin aspart	344,235	3.86%	Novo Nordisk	Diabetes mellitus type 1 and 2	Oct-1996	Mon-20XX
37	Humalog	Insulin lispro	304,866	6.15%	Eli Lilly and Company	Diabetes mellitus type 1 and 2	Apr-1996	Mon-20XX
38	Suboxone	Buprenorphine	321,892	-2.11%	Reckitt Benckiser Pharmaceuticals Inc.	Pain; opioid addiction	Aug-2000	Mon-20XX
40	Viagra	Sildenafil	300,463	3.26%	Pfizer	Erectile dysfunction	Mar-1998	Mar-2012
41	Seroquel XR	Quetiapine	291,494	2.22%	Generic	Psychosis; depression	Sep-1997	Mar-2012
33	Incivo	Telaprevir	370,899	0.00%	Johnson & Johnson	Hepatitis C^{[citation needed]}	Dec-1990	Mon-20XX
35	AndroGel	Testosterone gel	351,737	5.47%	Generic	Low testosterone levels	Oct-2002	Oct-2016
37	Enoxaparin	Enoxaparin	341,184	6.55%	Generic	Deep-vein thrombosis	Mar-1993	2012-Aug
38	Ritalin	Methylphenidate	327,346	2.26%	Generic	Attention deficit hyperactivity disorder	Aug-2000	Mon-20XX
41	ProAir HFA	Salbutamol	306,461	10.87%	Teva Pharmaceuticals	Asthma; chronic obstructive pulmonary disease	Oct-1996	Mon-20XX
43	Alimta	Pemetrexed	302,728	6.00%	Eli Lilly and Company	Cancer	Feb-2004	Mon-20XX
44	Victoza	Liraglutide	301,414	9.59%	Novo Nordisk	Diabetes mellitus type 2	May-1909	Mon-20XX
47	Synagis	Palivizumab	289,704	0.00%	MedImmune	RSV infection	Feb-1998	Aug-2012
48	Avonex	Interferon beta 1a	281,554	-1.43%	Biogen Idec	Multiple sclerosis	May-1996	Mon-20XX
49	Renvela	Sevelamer	280,917	21.44%	Generic	Hyperphosphatemia	Apr-2002	Apr-2016 ^[10]
50	Rebif	Interferon beta 1a	280,548	-6.27%	Serono	Multiple sclerosis	Feb-1998	Mon-20XX
51	Cialis	Tadalafil	280,518	4.58%	Eli Lilly and Company, Lilly Icos	Erectile dysfunction	Nov-2002	2017-Nov
52	Gilenya	fingolimod	272,701	4.05%	Novartis Corporation	Multiple sclerosis	Feb-2000	2007-Jan
53	Nasonex	Mometasone	272,345	5.67%	Schering-Plough	Allergic rhinitis	Oct-1997	2018-Oct
54	Stelara	Ustekinumab	270,598	12.47%	Johnson & Johnson	Psoriasis; psoriatic arthritis	Apr-2000	Mon-20XX
55	Restasis	Ciclosporin ophthalmic emulsion	268,463	6.30%	Allergan, Inc, Lilly Icos	Dry eye syndrome	Nov-2002	Mon-20XX
56	Budesonide	Budesonide	268,201	26.81%	Generic	Asthma	Aug-2000	Mon-20XX
57	Acetaminophen/hydrocodone	Acetaminophen/hydrocodone	264,814	6.67%	Generic	Pain	Aug-2000	Mon-20XX
58	Flovent HFA	Fluticasone propionate	263,072	13.97%	GlaxoSmithKline	Asthma	Mar-1996	Mon-20XX
59	Lovaza	Omega-3 fatty acid ethyl esters	258,177	2.90%	GlaxoSmithKline	Cholesterol	Jun-2001	Mon-20XX
60	Prezista	Darunavir	251,372	3.54%	Johnson & Johnson	HIV infection	Jun-2006	Mon-20XX
61	Isentress	Raltegravir	248,924	0.72%	Merck & Co., Inc.	HIV Infection	Dec-1998	Mon-20XX
62	Janumet	Sitagliptin/metformin	247,150	4.65%	Merck & Co., Inc.	Diabetes mellitus type 2	Dec-1998	Mon-20XX
63	Procrit, Eprex	Epoetin alfa	241,535	-10.09%	Johnson & Johnson	Anemia	Dec-1990	Mon-20XX
64	Doxycycline	Doxycycline	241,381	-5.65%	Generic	Bacterial infections	Dec-1996	Nov-2011
65	Orencia	Abatacept	241,149	1.65%	Bristol-Myers Squibb Company	Rheumatoid arthritis	Aug-2000	Mon-20XX
66	Amphetamine/dextroamphetamine	Amphetamine mixed salts	240,482	2.78%	Generic	Attention deficit hyperactivity disorder; narcolepsy	Feb-2004	Mon-20XX
67	Vesicare	Solifenacin	240,435	5.37%	Astellas Pharma US	Overactive bladder	Feb-2000	2018-Nov
68	Dexilant	Dexlansoprazole	238,897	7.57%	Takeda Pharmaceuticals North America, Inc	Gastrointestinal disorders	Dec-2004	Jul-2012
69	Humalog KwikPen	Insulin lispro	238,418	11.02%	Eli Lilly and Company	Diabetes mellitus type 1 and 2	Apr-1996	Mon-20XX
70	Neupogen	Filgrastim	229,912	-2.70%	Amgen	Neutropenia	Feb-1991	Mon-20XX
71	Lidocaine	Lidocaine	225,903	0.00%	Generic	Pain	Mar-1999	Mon-20XX
72	Lunesta	Eszopiclone	225,101	5.24%	Generic	Insomnia	Dec-2004	April-2015
73	Fenofibrate	Fenofibrate	223,300	-2.22%	Generic	Cholesterol	Feb-1998	Mon-20XX
74	Zytiga	Abiraterone	222,026	11.86%	Janssen Biotech, Inc.	Prostate Cancer	Dec-1998	April-2015
75	Reyataz	Atazanavir	217,793	-1.38%	Bristol-Myers Squibb	HIV infection	Jan-2003	Mon-20XX
76	Sensipar	Cinacalcet	216,657	13.71%	Amgen Inc.	Hyperparathyroidism	Apr-2000	Mon-20XX
77	Metoprolol	Metoprolol	215,111	2.99%	Generic	Hypertension	Jan-1992	Mon-20XX
78	AcipHex	Rabeprazole	214,251	10.03%	Janssen Pharmaceuticals, Inc, Johnson & Johnson	Gastrointestinal disorders	Aug-1999	Nov-2013
79	Synthroid	Levothyroxine	213,424	-2.50%	Generic	Hypothyroidism	May-1999	Expired
80	Avonex Pen	Olmesartan	211,917	13.59%	Biogen Idec, Forest Laboratories	Hypertension	Apr-2002	Apr-2016
81	Prevnar 13	Pneumococcal conjugate vaccine	209,367	6.41%	Pfizer	Pneumococcal disease	Feb-2000	Jan-2007
82	Xolair	Omalizumab	207,891	1.91%	Genentech, Novartis	Asthma	2003	Mon-20XX
83	Lipitor	Atorvastatin	207,542	4.23%	Generic	Cholesterol	Dec-1996	Nov-2011 ^[12]
84	levothyroxine	Levothyroxine	204,755	0.00%	Generic	Hypothyroidism	Aug-1990	Mon-20XX
85	Benicar	Olmesartan/hydrochlorothiazide	203,336	3.22%	Daiichi Sankyo	Hypertension	Jun-1909	Mon-2016
86	Stribild	Elvitegravir/cobicistat/emtricitabine/tenofovir	202,642	0.00%	Gilead Sciences	HIV/AIDS	Apr-2000	Mon-20XX^[13]
87	Zostavax	Zostavax	202,240	15.17%	Eisai, Merck & Co.	Herpes zoster	Aug-1999	May-2013
88	Pradaxa	Dabigatran	200,697	-0.53%	Boehringer Ingelheim, Lilly Icos	Oral anticoagulant	Oct-2010	Mon-20XX
89	Vytorin	Ezetimibe/simvastatin	199,625	-3.02%	Merck & Co., Schering-Plough	Cholesterol	Jul-2004	Mon-20XX
90	Tamiflu	Oseltamivir	197,718	0.00%	Chugai Pharmaceutical, Hetero Drugs, Roche	Influenza	Oct-1999	Mon-20XX
91	Xgeva	Denosumab	197,711	3.24%	Amgen	Osteoporosis	Nov-2010	Mon-20XX
92	Evista	Raloxifene	196,929	-4.31%	Eli Lilly and Company, Chugai Pharmaceutical	Osteoporosis	Dec-1997	Jan-2013
93	Xeloda	Capecitabine	194,044	6.52%	Generic	Cancer	Jun-1909	Mon-20XX ^[14]
94	Aranesp	Darbepoetin alfa	185,225	-9.22%	Amgen Inc.	Anemia	Jun-2001	Mon-20XX
95	Ventolin HFA	Salbutamol	183,060	0.00%	GlaxoSmithKline	Asthma; chronic obstructive pulmonary disease	May-1981	Mon-20XX
96	divalproex sodium	Valproate	181,554	0.00%	Generic	Epilepsy and bipolar disorder ^[15]	Jun-1909	Mon-20XX
97	Afinitor	Everolimus	180,719	0.03%	Novartis	Cancer	Jun-1909	Mon-20XX
98	Betaseron, Betaferon	Interferon beta 1b	179,216	-3.72%	Bayer	Multiple sclerosis	Jul-1993	Mon-20XX
99	Adderall XR	Amphetamine mixed salts	177,505	3.31%	Generic	Attention deficit hyperactivity disorder	Oct-2001	Mon-20XX
100	Complera	Emtricitabine/Rilpivirine/Tenofovir disoproxil fumarate	174,933	0.00%	Gilead Sciences, Inc.	HIV	Jun-20XX	Mon-20XX

References

^ "Medicine Spending and Affordability in the United States: Understanding Patients' Costs for Medicines". IQVIA Institute for Human Data Science. Archived from the original on 17 Sep 2020.
^ "Top 15 Best-Selling Drugs of 2018". GEN - Genetic Engineering and Biotechnology News. 2019-03-11. Retrieved 2019-05-30.
^ "The Top 15 Best-Selling Drugs of 2016". 6 March 2017.
^ "Top drugs by sales revenue in 2015: Who sold the biggest blockbuster drugs?". March 10, 2016. Retrieved October 19, 2016.
^ Drugs.com U.S. Pharmaceutical Sales - Q4 2013, updated Feb. 2014
^ Patent Terms Extended Under 35 USC §156
^ Orange Book Trade Name Search
^ "Generic OxyContin Availability". Drugs.com.
^ Unknown. "Generic Namenda Availability - Drugs.com". www.drugs.com. Drugs.com. Retrieved 21 December 2015.
^ Donohue, Mark. "Impax Laboratories Inc. - Impax Launches Authorized Generic RENVELA®". investors.impaxlabs.com. Impax Laboratories. Retrieved 21 December 2015.
^ Armstrong, Drew; Decker, Susan. "Pfizer's blockbuster blue pill Viagra set to go generic in 2015". Indianapolis Star. Retrieved 25 December 2015.
^ "Atorvastatin: Drug Uses, Dosage, Side Effects - Drugs.com". www.drugs.com. drugs.com. Retrieved 21 December 2015.
^ "HIV Treatment". www.stribild.com.
^ Walsh, Sandy. "Press Announcements - FDA approves first generic capecitabine to treat colorectal and breast cancers". www.fda.gov. United States Food and Drug Administration. Retrieved 21 December 2015.
^ "Valproic Acid". The American Society of Health-System Pharmacists. Archived from the original on 2017-07-31. Retrieved Oct 23, 2015.

[1] "Medicine Spending and Affordability in the United States: Understanding Patients' Costs for Medicines". IQVIA Institute for Human Data Science. Archived from the original on 17 Sep 2020.

[2] "Top 15 Best-Selling Drugs of 2018". GEN - Genetic Engineering and Biotechnology News. 2019-03-11. Retrieved 2019-05-30.

[3] "The Top 15 Best-Selling Drugs of 2016". 6 March 2017.

[4] "Top drugs by sales revenue in 2015: Who sold the biggest blockbuster drugs?". March 10, 2016. Retrieved October 19, 2016.

[5] Drugs.com U.S. Pharmaceutical Sales - Q4 2013, updated Feb. 2014

[6] Patent Terms Extended Under 35 USC §156

[7] Orange Book Trade Name Search

[8] "Generic OxyContin Availability". Drugs.com.

[9] Unknown. "Generic Namenda Availability - Drugs.com". www.drugs.com. Drugs.com. Retrieved 21 December 2015.

[10] Donohue, Mark. "Impax Laboratories Inc. - Impax Launches Authorized Generic RENVELA®". investors.impaxlabs.com. Impax Laboratories. Retrieved 21 December 2015.

[11] Armstrong, Drew; Decker, Susan. "Pfizer's blockbuster blue pill Viagra set to go generic in 2015". Indianapolis Star. Retrieved 25 December 2015.

[12] "Atorvastatin: Drug Uses, Dosage, Side Effects - Drugs.com". www.drugs.com. drugs.com. Retrieved 21 December 2015.

[13] "HIV Treatment". www.stribild.com.

[14] Walsh, Sandy. "Press Announcements - FDA approves first generic capecitabine to treat colorectal and breast cancers". www.fda.gov. United States Food and Drug Administration. Retrieved 21 December 2015.

[15] "Valproic Acid". The American Society of Health-System Pharmacists. Archived from the original on 2017-07-31. Retrieved Oct 23, 2015.

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