Townsville CBD has many heritage-listed sites, including:
- Castle Hill Road: Castle Hill[1]
- 2–4 Cleveland Terrace: Drystone Wall, Melton Hill[2]
- 20 Cleveland Terrace: The Rocks Guesthouse[3]
- 26 Cleveland Terrace: Warringa[4]
- 36 Cleveland Terrace: St James Cathedral[5]
- 36 Cleveland Terrace: Synod Hall[6]
- Clifton Street: Australian Institute of Tropical Medicine Building[7]
- 87 Flinders Street: Tattersalls Hotel[8]
- 101–111 Flinders Street: Bank of New South Wales[9]
- 104–106 Flinders Street: Queensland Building[10]
- 108–124 Flinders Street: Burns Philp Building[11]
- 143–149 Flinders Street East: First AMP Building (later Magnetic House)[12]
- 173 Flinders Street: Australian Joint Stock Bank Building[13]
- 175 Flinders Street: Queens Building[14]
- 181–183 Flinders Street: Atkinson & Powell Building[15]
- 193 Flinders Street: T. Willmetts & Sons Printery[16]
- 197–203 Flinders Street: Stanton House[17]
- 205–207 Flinders Street: former Commercial Bank of Australia Building (Atinee Building)[18]
- 212–260 Stanley Street: Block A, Townsville Technical College[19]
- 221–223 Flinders Street: Clayton's Apothecaries' Hall[20]
- 224 Flinders Street: Howard Smith Company Building (later Agora House)[21]
- 232–234 Flinders Street: Aplin Brown & Company Building[22]
- 241–245 Flinders Street: Rooney Building[23]
- 247 Flinders Street: Samuel Allen & Sons Building[24]
- 252–270 Flinders Street: former Townsville Post Office (now The Brewery)[25]
- 253–259 Flinders Street: Perc Tucker Regional Gallery[26]
- 272–278 Flinders Street: Commonwealth Bank Building[27]
- 295–303 Flinders Street: Queensland National Bank[28]
- 337–343 Flinders Street: Westpac Bank[29]
- 408–410 Flinders Street: Henlein & Co Building[30]
- 416–418 Flinders Street: Second AMP Building[31]
- 419 Flinders Street: State Government Offices (Flinders Street)[32]
- 500 Flinders Street: Great Northern Hotel[33]
- 502 & 792 Flinders Street: Old Townsville railway station[34]
- 719–741 Flinders Street: Lion Brewery[35]
- 799 Flinders Street: Saints Theodores Greek Orthodox Church[36]
- 21 Lawson Street: Rosebank House[37]
- Stanley Street: Townsville School of Arts[38]
- 266 Stanley Street: Sacred Heart Cathedral[39]
- Stokes Street: Victoria Bridge[40]
- The Strand: Anzac Memorial Park[41]
- The Strand: Queen's Hotel[42]
- The Strand: Tobruk Memorial Baths[43]
- 1–13 Sturt Street: Dalgety Offices[44]
- 35 Sturt Street: Osler House[45]
- 42 Sturt Street: Commonwealth Offices[46]
- 81 Sturt Street: former Townsville Magistrates Court[47]
- 485 Sturt Street: Townsville Masonic Hall[48]
- 513 Sturt Street: Townsville Baptist Church[49]
- Wickham Street: Townsville Customs House[50]
- 12–14 Wickham Street: State Government Offices (Wickham Street)[51]