Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells.
IRS-1, for example, is an IRS protein that contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin receptor contains a NPXY motif. The PTB-domain binds the NPXY sequence. Thus, the insulin receptor binds IRS.
Genes edit
- IRS1 (see also Insulin receptor substrate 1)
- IRS2 (see also Insulin receptor substrate 2)
- IRS3P - a pseudogene
- IRS4
References edit
- van der Geer P, Wiley S, Pawson T (1999). "Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site". Oncogene. 18 (20): 3071–5. doi:10.1038/sj.onc.1202879. PMID 10340378.
🔥 Top keywords: Akademia e Shkencave e RPS te ShqiperiseAlexandria Ocasio-CortezBilderberg GroupCristiano RonaldoDong XiaowanMinecraftOperation GladioPrimal cutRiot FestStrictly Come Dancing (series 7)Main PageSpecial:SearchMichael Mosley (broadcaster)Carlos AlcarazAlexander ZverevWikipedia:Featured picturesChirag PaswanHit Man (2023 film)Union Council of Ministers2024 ICC Men's T20 World Cup2024 Indian general election2024 European Parliament electionCleopatraKinjarapu Ram Mohan NaiduDeaths in 2024Glen PowellProject 2025Nirmala SitharamanPawan KalyanBad Boys: Ride or DieICC Men's T20 World CupAdria ArjonaNarendra ModiIga ŚwiątekRamoji RaoS. JaishankarAlan HansenJack NicklausList of prime ministers of India.xxxYouTubeRam Vilas PaswanUFC on ESPN: Cannonier vs. ImavovSabrina CarpenterUEFA Euro 2024The Acolyte (TV series)Barry KeoghanChristopher ReeveAnnpurna Devi