Galegine is a toxic chemical compound that has been isolated from Galega officinalis.[1] It has also been found to be the principal cause of the toxicity of poison sedge (Schoenus asperocarpus).[2]
Names | |
---|---|
IUPAC name 2-(3-Methylbut-2-enyl)guanidine | |
Other names
| |
Identifiers | |
3D model (JSmol) | |
ChEBI | |
ChEMBL | |
ChemSpider | |
KEGG | |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
| |
| |
Properties | |
C6H13N3 | |
Molar mass | 127.191 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Galegine was used in the 1920s as a pharmaceutical treatment for diabetes;[3] however, because of its toxicity, its use was soon supplanted by superior alternatives. Research on galegine eventually led to the development of metformin which is used today for treatment of type 2 diabetes.[3]
See also
editReferences
edit- ^ Oldham, Michelle; Ransom, Corey V.; Ralphs, Michael H.; Gardner, Dale R. (2011). "Galegine Content in Goatsrue (Galega officinalis) Varies by Plant Part and Phenological Growth Stage". Weed Science. 59 (3): 349–352. doi:10.1614/WS-D-10-00169.1.
- ^ Huxtable, C. R.; Dorling, P. R.; Colegate, S. M. (1993). "Identification of galegine, an isoprenyl guanidine, as the toxic principle of Schoenus asperocarpus (poison sedge)". Australian Veterinary Journal. 70 (5): 169–71. doi:10.1111/j.1751-0813.1993.tb06120.x. PMID 8343085.
- ^ a b Bailey, CJ; Day, C. (2004). "Metformin: Its botanical background". Practical Diabetes International. 21 (3): 115–117. doi:10.1002/pdi.606.
🔥 Top keywords: Akademia e Shkencave e RPS te ShqiperiseAlexandria Ocasio-CortezBilderberg GroupCristiano RonaldoDong XiaowanMinecraftOperation GladioPrimal cutRiot FestStrictly Come Dancing (series 7)Main PageSpecial:SearchWikipedia:Featured picturesUEFA Euro 2024Derek JeterJamal MusialaBridgertonInside Out 2UEFA European Championship2024 ICC Men's T20 World CupCleopatraThe Boys (TV series)The Boys season 4Deaths in 2024Pawan KalyanNATO phonetic alphabetUEFA Euro 2020ChatGPTG7Giorgia Meloni.xxxYouTubeNicola CoughlanGermany national football teamBiggest ball of twineOpinion polling for the 2024 United Kingdom general electionJuneteenthJerry WestFlag Day (United States)Project 2025Scotland national football teamJulian NagelsmannDutch rollAndrew McCarthyDonald TrumpThe Acolyte (TV series)ICC Men's T20 World CupFlorian WirtzHit Man (2023 film)