Cyclopyrrolones are a family of hypnotic and anxiolytic nonbenzodiazepine drugs with similar pharmacological profiles to the benzodiazepine derivatives.
![](http://upload.wikimedia.org/wikipedia/commons/thumb/0/01/Cyclopyrrolone.svg/222px-Cyclopyrrolone.svg.png)
Although cyclopyrrolones are chemically unrelated to benzodiazepines, they function via the benzodiazepine receptor of neurotransmitter GABA.[1] The best-known cyclopyrrolone derivatives are zopiclone (Imovane) and its active single-enantiomer component, eszopiclone (Lunesta), which are used to treat insomnia, and have a known potential for abuse. Other cyclopyrrolones include:
- Pagoclone – anxiolytic
- Pazinaclone – anxiolytic
- Suproclone – anxiolytic
- Suriclone – anxiolytic
References
edit- ^ Jones, Ian R; Sullivan, Gary (January 10, 1998). "Physical dependence on zopiclone: case reports". The BMJ. 316 (117). doi:10.1136/bmj.316.7125.117. PMC 2665371. Retrieved April 21, 2021.
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