How to Use Benzoyl Peroxide and Tretinoin at the Same Time

Download Article

The proper timing and schedule for your acne regimen

Download Article

Using Both

|

Using Benzoyl Peroxide

|

Using Tretinoin

|

Expert Q&A

Topical tretinoin and benzoyl peroxide are commonly used to treat acne, but some dermatologists warn against using both products at the same time.^{[1]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source} Previous studies suggested that benzoyl peroxide may reduce the effectiveness of tretinoin, but recent studies show that this is not the case—it’s perfectly safe to use both products, as long as you take the proper precautions.^{[2]XTrustworthy SourcePubMed CentralJournal archive from the U.S. National Institutes of HealthGo to source} In this article, we’ll teach you how to safely use topical tretinoin and benzoyl peroxide together, plus provide information on potential side effects and when to see a dermatologist.

Things You Should Know

Alternate tretinoin and benzoyl peroxide daily for the first 2 weeks to get your skin used to the medications. After 2 weeks, start to use both on the same day.
Wear a sunscreen that's SPF 15 or higher every day, since tretinoin often causes increased sensitivity to the sun.
Use plenty of lotion to combat dry skin caused by the medications, and always follow your doctor's prescription instructions closely to prevent other side effects.

Method 1

Method 1 of 3:

Using Topical Tretinoin and Benzoyl Peroxide Concurrently

Download Article

1
Alternate the two medications for the first 2 weeks. While it's safe to use tretinoin and benzoyl peroxide concurrently, some dermatologists worry that it may cause mild to severe skin irritation. This is because benzoyl peroxide products typically contain a peeling agent.^{[3]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source} However, studies show that the 2 medications may be combined if precautions are taken to reduce the chances of irritation.^{[4]XTrustworthy SourceAmerican Academy of Family PhysiciansOrganization devoted to improving the health of patients, families, and communitiesGo to source}
- Alternate which product you apply to your skin every day for the first 2 weeks.^{[5]XTrustworthy SourceAmerican Academy of Family PhysiciansOrganization devoted to improving the health of patients, families, and communitiesGo to source} For example, if you use tretinoin on Monday, wait until Tuesday to use benzoyl peroxide.
- Continue alternating products until 2 weeks have passed to minimize the risk of irritation. After that point, your doctor may advise you that it's safe to use both products at the same time.
2
Talk to a dermatologist before using both medications at the same time. After the first 2 weeks, your skin should be a bit more used to both products and you may want to use them at the same time each day. Talk to your dermatologist before making any changes to your prescription medication regimen and ask about the potential risks and benefits of using treatments concurrently.^{[6]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- Some studies show that benzoyl peroxide can inactivate tretinoin, so it may be best to apply benzoyl peroxide in the morning and tretinoin at night. However, gel formulations of tretinoin are not affected by benzoyl peroxide and can be used together.^{[7]XTrustworthy SourceScience DirectOnline archive of peer-reviewed research on scientific, technical and medical topicsGo to source}
Advertisement
3
Protect your skin from the sun, wind, and cold weather. Tretinoin increases your skin’s sensitivity to the sun, and it can also cause dryness and redness—especially in people with brown or Black skin.^{[8]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source} When using tretinoin, apply sunscreen with a sun protection factor (SPF) of 15 or higher every day, and wear protective clothing and hats any time you step outside.^{[9]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- Even if you apply tretinoin at night, your skin is still susceptible to sun damage during the day. Stay out of the sun as much as possible to minimize your risk of sunburn.^{[10]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- During the first 6 months of use, your skin will be extra sensitive to sun and weather-related damage.^{[11]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source} Take precautions to shield and protect your face, such as wearing a wide-brimmed hat in the summer or wrapping a scarf around your face on cold or windy days.
4
Moisturize your skin daily in the morning and evening. To minimize the side effects of both products, apply a mild moisturizer to your skin each day.^{[12]XResearch source} Tretinoin is known to cause skin irritation, including warmth or stinging of the skin, redness, blistering, flaking, scaling, or crusting.^{[13]XResearch source} Benzoyl peroxide is known to cause dryness, tingling, and peeling of the skin.^{[14]XResearch source}
- Look for moisturizers that are unscented, alcohol-free, and that aim to protect your skin barrier.
5
Visit a doctor if your skin irritation becomes severe. Most side effects of these medications are minimal, and will eventually go away on their own with continued use. However, some reactions can be signs of a larger problem, such as a possible overdose of the medication. Seek emergency care right away if you experience any of the following side effects:^{[15]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- Pain
- Burning
- Blistering
- Dryness
- Itching
- Peeling
- Redness
- Scaling
- Stinging
- Changes in skin color
- Swelling on areas where the medication is applied

Method 2

Method 2 of 3:

Using Benzoyl Peroxide Correctly

Download Article

1
Talk to your doctor about using benzoyl peroxide. Your dermatologist will recommend the best treatment for your skin type and skin concerns, and the dosage of your specific medication will vary, depending on the strength of the medication and the length of time you take the medication.^{[16]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source} Follow your doctor’s instructions and the directions on the label to ensure you apply the product safely.
- Many over-the-counter products containing benzoyl peroxide are available without a prescription, including soap, lotion, gel, cream, and foam.^{[17]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- Common brand names containing benzoyl peroxide available in the U.S. include: Acne, Acne 10 Gel, Acne Wash, Benzac, Benzagel, Benziq, and Brevoxyl.^{[18]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
2
Perform a patch test before using benzoyl peroxide. Benzoyl peroxide can irritate the skin, so if you’re using an over-the-counter product for the first time, apply a small amount to the affected area for 3 days.^{[19]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source} If you don’t experience irritation during this time, you may continue to use it daily. However, always proceed with caution because it is a peeling product.
- Never use benzoyl peroxide on skin that has cuts, scrapes, or sunburns. If it gets in these areas, rinse it off with water right away.^{[20]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
3
Apply benzoyl peroxide cream, gel, or lotion. If you're using a cream, gel, or lotion form of benzoyl peroxide, follow the instructions on the packaging closely. Make sure your skin is clean and dry before applying your product, and only use as much as the instructions indicate.^{[21]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- Use a non-medicated soap and lukewarm water to wash the affected area before using benzoyl peroxide. When you're finished, gently pat your skin dry with a clean towel.^{[22]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- Apply the product as directed by your doctor, and do not use more of it, do not use it more often, and do not use it for a longer time period than advised.^{[23]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
If you're using a benzoyl peroxide product that comes in a soap or cleansing lotion/bar form, you don’t need to wash your face before applying it. Follow the directions on the packaging and only use as much product as the instructions (or your doctor) recommends.^{[24]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}

Method 3

Method 3 of 3:

Treating Acne Safely with Tretinoin

Download Article

1
Consult your doctor about using tretinoin. Tretinoin gel is only available by prescription, and it treats acne by keeping your pores clear.^{[25]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source} If your doctor prescribes you tretinoin (or any other retinoid product), let them know about any benzoyl peroxide products you currently use, including over-the-counter products.
- Common brand-name tretinoin products available in the U.S. include Atralin, Avita, Refissa, Renova, Retin-A, and Tretin-X.^{[26]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- If you are pregnant or trying to get pregnant, avoid using tretinoin. Some forms of tretinoin, such as isotretinoin, may cause birth defects or other pregnancy-related problems.^{[27]XTrustworthy SourcePubMed CentralJournal archive from the U.S. National Institutes of HealthGo to source}
- If you plan to take birth control pills while using tretinoin, tell your doctor the name of the pill you will use. Some oral contraceptives are not effective when taken with tretinoin, and your doctor may recommend that you take 2 forms of birth control during the entire treatment period and for one month after.^{[28]XTrustworthy SourceMedlinePlusCollection of medical information sourced from the US National Library of MedicineGo to source}
2
Take proper precautions before applying tretinoin to your skin. Topical tretinoin often causes skin irritation, especially during the first 3 weeks of use.^{[29]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source} If your skin irritation becomes severe or your acne shows no signs of improvement after 8 to 12 weeks of continued use, talk to your doctor about possible complications.^{[30]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- Avoid applying any other topical medications on the same area for one hour before and after using tretinoin.^{[31]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- To minimize skin irritation, do not use any skin products that are abrasive or dry out your skin, including skin cleansers and products containing alcohol.^{[32]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
3
Apply tretinoin to the affected area as directed. To ensure you use tretinoin correctly, follow your doctor’s instructions carefully. Do not apply more tretinoin in a given dose than your doctor recommends, and do not use this medication more than once in a given day. If you miss a dose, skip that dose completely and wait for the next scheduled application time.^{[33]XResearch source}
- Wash the affected area with a mild cleanser and warm water at least 20-30 minutes before applying tretinoin, and make sure to wash your hands before and after using the product.^{[34]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- To use the gel, cream, or lotion form of tretinoin, apply just enough product to lightly cover the affected area. You only need a pea-sized amount of tretinoin to cover the entire face.^{[35]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- To apply the liquid form of tretinoin, use clean fingertips, a clean piece of gauze, or a clean cotton swab to cover the affected area.^{[36]XTrustworthy SourceMayo ClinicEducational website from one of the world's leading hospitalsGo to source}
- Tretinoin is known to cause photosensitivity, so apply a small amount once daily before bedtime.^{[37]XTrustworthy SourceAmerican Academy of Family PhysiciansOrganization devoted to improving the health of patients, families, and communitiesGo to source}

Expert Q&A

Search

Add New Question

Question
What order should I apply them in if I'm using both at the same time?
Janice Litza, MD
Board Certified Family Medicine Physician
Dr. Litza is a Board Certified Family Medicine Physician based in Racine, Wisconsin. With over 25 years of educational and professional experience, she has extensive experience providing full-spectrum Family Medicine, including obstetrics, newborn care, and hospital medicine. She is currently the Residency Program Director for Family Medicine at Ascension. Dr. Litza received her MD from the University of Wisconsin-Madison School of Medicine and Public Health and has completed additional fellowship training in Integrative Medicine through the University of Arizona.
Janice Litza, MD
Board Certified Family Medicine Physician
Expert Answer
The order may not matter. In fact, you may even mix both together in small amounts. Apply a thin layer of the mixture on your skin to use both at the same time.
Thanks! We're glad this was helpful.
Thank you for your feedback.
If How.com.vn has helped you, please consider a small contribution to support us in helping more readers like you. We’re committed to providing the world with free how-to resources, and even $1 helps us in our mission.Support How.com.vn
Yes No
Not Helpful 0 Helpful 9
Question
I have used benzoyl peroxide for nearly one month. During the first two weeks, my acne got better. But in the last two weeks, I noticed my acne worsened. I feel itchiness and burning. Redness and new pimples have appeared. Am I allergic?
Janice Litza, MD
Board Certified Family Medicine Physician
Dr. Litza is a Board Certified Family Medicine Physician based in Racine, Wisconsin. With over 25 years of educational and professional experience, she has extensive experience providing full-spectrum Family Medicine, including obstetrics, newborn care, and hospital medicine. She is currently the Residency Program Director for Family Medicine at Ascension. Dr. Litza received her MD from the University of Wisconsin-Madison School of Medicine and Public Health and has completed additional fellowship training in Integrative Medicine through the University of Arizona.
Janice Litza, MD
Board Certified Family Medicine Physician
Expert Answer
You may not be allergic. The medicine may be drying out your skin, and your skin might be reacting to this by making more oil. Make sure you are using a cleanser and moisturizer and not just acne medicine. Adding a new topical medicine will improve acne when you have a healthy skin care routine as well.
Thanks! We're glad this was helpful.
Thank you for your feedback.
If How.com.vn has helped you, please consider a small contribution to support us in helping more readers like you. We’re committed to providing the world with free how-to resources, and even $1 helps us in our mission.Support How.com.vn
Yes No
Not Helpful 1 Helpful 4